Elemental Analysis

 

 

Synchronous Vertical Dual View Inductively Coupled Plasma-Optical Emission Spectroscopy (SVDV-ICP-OES)

 

Atomic Absorption Spectroscopy (AAS) or Atomic Emission Spectroscopy (AES)

 

 

 

Synchronous Vertical Dual View Inductively Coupled Plasma-Optical Emission Spectroscopy (SVDV-ICP-OES)

 

 

SVDV is a configuration used in ICP-OES instruments that enhances the analytical capabilities of the technique. In traditional ICP-OES, the sample is aspirated and atomised within the inductively coupled plasma, and the emitted light is collected by a single optical path and passed through a single optical grating system to measure the emitted spectra.

 

SVDV introduces two simultaneous views (axial and radial) of the plasma emission, which provides distinct advantages: Axial view is optimised for the detection of low concentration elements and trace metals, providing a longer path length for the emitted light, increasing sensitivity for trace analysis and Radial view which measures high concentration elements and major components. It provides higher spectral resolution and lower background noise for elements that emit strong signals. SVDV-ICP-OES is a technique used for the detection of elements at trace (parts of million) levels in numerous sample types, which provides a highly reliable technique due to good stability, limited spectral interferences and low matrix effects.

 

 

Equipment

 

  • Agilent SVDV-ICP-OES 5110.
  • Agilent SVDV-ICP-OES 5900.

 

  • SVDV ICP OES

    Life science capabilities and applications

    • Extensive work carried out on pharmaceutical APIs and finished products as well as various raw materials and food products.
    • Extensive experience in pharmaceutical extractable and leachable studies.
    • Capability of analysing samples for up to 25 elements by AAS or AES (other elements available upon request by AES).
    • Excipient and Raw Material Analysis
    • Able to analyse a variety of matrices, including samples in organic solvents
    • Technique recognised by all world pharmacopeia (EP, USP, JP).
    • Pharmacopeial testing including nickel in sorbitol
    • Assay and Limit testing.
    • Investigatory and Comparative analysis.
    • Method development for a wide variety of matrices.
    • Method validation and verification.

 

 

Atomic Absorption Spectroscopy (AAS) or Atomic Emission Spectroscopy (AES)

 

Atomic Absorption Spectroscopy (AAS) is a sensitive and selective technique designed for the quantitative determination of metallic elements within a sample. By measuring light absorption at element-specific wavelengths, AAS delivers quantitative accurate and reproducible results across a wide range of sample types. It is a proven, industry standard approach for elemental analysis in pharmaceutical and life science applications, including complex and organic solvent matrices.


AAS supports regulatory driven testing for Assays and elemental impurities in line with regulatory and pharmacopeial requirements. The technique offers high sensitivity combined with strong elemental selectivity to ensure reliable results covering a range from % to ppb. Its flexibility enables efficient testing of raw materials and finished products while rapid, consecutive analysis supports streamlined QC and R&D workflows in regulated environments.


RSSL offers a comprehensive suite of Atomic Absorption Spectroscopy (AAS) techniques to support routine and trace elemental analysis across Food, Pharmaceutical and Life Science applications. 


Using Flame AAS for efficient ppm-level testing, Graphite Furnace AAS for enhanced ppb-level sensitivity in complex matrices, Hydride Generation AAS for high-performance analysis of elements such as arsenic and selenium, and Cold Vapour AAS for ultra-trace mercury determination, our capabilities deliver accurate, selective and regulatory-ready results across a wide range of sample types.

 

 

Equipment

 

  • Agilent 200 Series AA - multiple instrument setups: flame, graphite furnace and hydride (cold vapour and furnace).
  • Analytic Jena ContrAA 800D: Flame/Graphite furnace with Hydride/Cold Vapour capability.

 

  • Agilent 200 Series AA

    Life science capabilities and applications

    • Pharmaceuticals: Essential for assessing raw materials and finished products to ensure compliance regarding metal content, elemental impurities, and trace metals.
    • Toxic and heavy metals - Arsenic (As), Barium (Ba), Beryllium (Be), Cadmium (Cd), Chromium (Cr), Lead (Pb), Mercury (Hg), Nickel (Ni), Selenium (Se)
    • Nutrients and minerals - Calcium (Ca), Copper (Cu), Iron (Fe), Potassium (K), Magnesium (Mg), Manganese (Mn), Sodium (Na), Zinc (Zn)
    • Other elements - Aluminium (Al), Cobalt (Co), Lithium (Li), Molybdenum (Mo), Platinum (Pt), Tin (Sn), Titanium (Ti)
    • Complex and organic solvent matrices: It can be applied to complex matrices, such as the analysis of lead (Pb) and nickel (Ni) in polyols.
    • Clinical and Biological Analysis: Quantifies metal concentrations in various biological fluids and tissue samples for diagnostic and research purposes.
    • Elemental impurity and trace metal testing in complex matrices.
    • Recognised technique by world pharmacopeia (EP/BP, USP, JP)
    • Assay and Limit testing.
    • Investigatory and Comparative analysis.
    • Method development for a wide variety of matrices.
    • Method validation and verification 
  • Metals R2 5547 HR

    Food & consumer goods capabilities & applications

    • Nutrients and minerals – UKAS Accredited for; Calcium (Ca) Potassium (K), Magnesium (Mg), Sodium (Na). Other elements can be analysed alongside UKAS accredited elements upon request.
    • Other elements - Aluminium (Al), Cobalt (Co), Germanium (Ge), Lithium (Li), Molybdenum (Mo), Platinum (Pt), Silicon (Si), Silver (Ag), Tin (Sn), Titanium (Ti), Vanadium (V)
    • Food and Beverage Industry: Used for determining mineral content and screening for potentially toxic metals in consumer products like wine, beer, and dairy.